Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats
AbstractAtomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only by Ca level, but also a number of metallic and non-metallic elements in bone. Thus, in this study, the difference of metallic and non-metallic elements in ovariectomy-induced osteoporosis tibial and maxillary trabecular bone was investigated in comparison with sham operated normal bone by laser ablation inductively-coupled plasma mass spectrometry using a rat model. The results demonstrated that the average concentrations of 25Mg, 28Si, 39K, 47Ti, 56Fe, 59Co, 77Se, 88Sr, 137Ba, and 208Pb were generally higher in tibia than those in maxilla. Compared with the sham group, Ovariectomy induced more significant changes of these elements in tibia than maxilla, indicating tibial trabecular bones are more sensitive to changes of circulating estrogen. In addition, the concentrations of 28Si, 77Se, 208Pb, and Ca/P ratios were higher in tibia and maxilla in ovariectomised rats than those in normal bone at all time-points. The present study indicates that ovariectomy could significantly impact the element distribution and concentrations between tibia and maxilla. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Han, P.; Lu, S.; Zhou, Y.; Moromizato, K.; Du, Z.; Friis, T.; Xiao, Y. Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats. Int. J. Mol. Sci. 2016, 17, 977.
Han P, Lu S, Zhou Y, Moromizato K, Du Z, Friis T, Xiao Y. Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats. International Journal of Molecular Sciences. 2016; 17(6):977.Chicago/Turabian Style
Han, Pingping; Lu, Shifeier; Zhou, Yinghong; Moromizato, Karine; Du, Zhibin; Friis, Thor; Xiao, Yin. 2016. "Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats." Int. J. Mol. Sci. 17, no. 6: 977.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.