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Int. J. Mol. Sci. 2016, 17(6), 977; doi:10.3390/ijms17060977

Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats

1
Institute of Health and Biomedical innovation, Queensland University of Technology, Brisbane 4059, Australia
2
Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia 4072, Australia
3
Institute for Future Environments, Queensland University of Technology, Brisbane 4000, Australia
Pingping Han and Shifeier Lu are co-first authors.
*
Authors to whom correspondence should be addressed.
Academic Editor: Ihtesham ur Rehman
Received: 10 May 2016 / Revised: 31 May 2016 / Accepted: 3 June 2016 / Published: 21 June 2016
(This article belongs to the Special Issue Molecular Research on Dental Materials and Biomaterials)
View Full-Text   |   Download PDF [3318 KB, uploaded 21 June 2016]   |  

Abstract

Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only by Ca level, but also a number of metallic and non-metallic elements in bone. Thus, in this study, the difference of metallic and non-metallic elements in ovariectomy-induced osteoporosis tibial and maxillary trabecular bone was investigated in comparison with sham operated normal bone by laser ablation inductively-coupled plasma mass spectrometry using a rat model. The results demonstrated that the average concentrations of 25Mg, 28Si, 39K, 47Ti, 56Fe, 59Co, 77Se, 88Sr, 137Ba, and 208Pb were generally higher in tibia than those in maxilla. Compared with the sham group, Ovariectomy induced more significant changes of these elements in tibia than maxilla, indicating tibial trabecular bones are more sensitive to changes of circulating estrogen. In addition, the concentrations of 28Si, 77Se, 208Pb, and Ca/P ratios were higher in tibia and maxilla in ovariectomised rats than those in normal bone at all time-points. The present study indicates that ovariectomy could significantly impact the element distribution and concentrations between tibia and maxilla. View Full-Text
Keywords: ovariectomised rats; tibia; maxilla; LA-ICP-MS; osteoporosis ovariectomised rats; tibia; maxilla; LA-ICP-MS; osteoporosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Han, P.; Lu, S.; Zhou, Y.; Moromizato, K.; Du, Z.; Friis, T.; Xiao, Y. Multi-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats. Int. J. Mol. Sci. 2016, 17, 977.

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