Next Article in Journal
High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer
Previous Article in Journal
Metabolomic Studies of Oral Biofilm, Oral Cancer, and Beyond
Previous Article in Special Issue
Enrichment of Secondary Wastewater Sludge for Production of Hydrogen from Crude Glycerol and Comparative Evaluation of Mono-, Co- and Mixed-Culture Systems
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(6), 867; doi:10.3390/ijms17060867

Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria

1
Natural Products and Industrial Biochemistry Research Group (NPIB), Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam
2
Microbial Processes and Interactions (MiPI), Agro-biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
3
Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam
4
Food technology and Formulation, Agro-Biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
*
Authors to whom correspondence should be addressed.
Academic Editor: Marianne Su-Ling Brooks
Received: 26 March 2016 / Revised: 17 May 2016 / Accepted: 18 May 2016 / Published: 2 June 2016
(This article belongs to the Special Issue Bioprocess Engineering)
View Full-Text   |   Download PDF [1460 KB, uploaded 2 June 2016]   |  

Abstract

The literature presents a growing body of evidence demonstrating the positive effect of probiotics on health. Probiotic consumption levels are rising quickly in the world despite the fluctuation of their viability and functionality. Technological methods aiming at improving probiotic characteristics are thus highly wanted. However, microbial metabolic engineering toolbox is not available for this kind of application. On the other hand, basic microbiology teaches us that bacteria are able to exhibit adaptation to external stresses. It is known that adequately applied sub-lethal stress, i.e., controlled in amplitude and frequency at a given stage of the culture, is able to enhance microbial robustness. This property could be potentially used to improve the viability of probiotic bacteria, but some technical challenges still need to be overcome before any industrial implementation. This review paper investigates the different technical tools that can be used in order to define the proper condition for improving viability of probiotic bacteria and their implementation at the industrial scale. Based on the example of Bifidobacterium bifidum, potentialities for simultaneously improving viability, but also functionality of probiotics will be described. View Full-Text
Keywords: biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nguyen, H.-T.; Truong, D.-H.; Kouhoundé, S.; Ly, S.; Razafindralambo, H.; Delvigne, F. Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria. Int. J. Mol. Sci. 2016, 17, 867.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top