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Int. J. Mol. Sci. 2016, 17(6), 854; doi:10.3390/ijms17060854

Activation of DNA Damage Response Induced by the Kaposi’s Sarcoma-Associated Herpes Virus

1
Clinical Pathology and Microbiology Department, San Gallicano Institute, IRCCS, Rome 00144, Italy
2
Infectious Disease Consultant, San Gallicano Institute, IRCCS, Rome 00144, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Guillermo T. Sáez
Received: 29 April 2016 / Revised: 23 May 2016 / Accepted: 27 May 2016 / Published: 1 June 2016
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2016)
View Full-Text   |   Download PDF [1330 KB, uploaded 1 June 2016]   |  

Abstract

The human herpes virus 8 (HHV-8), also known as Kaposi sarcoma-associated herpes virus (KSHV), can infect endothelial cells often leading to cell transformation and to the development of tumors, namely Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic variant of multicentric Castleman’s disease. KSHV is prevalent in areas such as sub-Saharan Africa and the Mediterranean region presenting distinct genotypes, which appear to be associated with differences in disease manifestation, according to geographical areas. In infected cells, KSHV persists in a latent episomal form. However, in a limited number of cells, it undergoes spontaneous lytic reactivation to ensure the production of new virions. During both the latent and the lytic cycle, KSHV is programmed to express genes which selectively modulate the DNA damage response (DDR) through the activation of the ataxia telangiectasia mutated (ATM) pathway and by phosphorylating factors associated with the DDR, including the major tumor suppressor protein p53 tumor suppressor p53. This review will focus on the interplay between the KSHV and the DDR response pathway throughout the viral lifecycle, exploring the putative molecular mechanism/s that may contribute to malignant transformation of host cells. View Full-Text
Keywords: DNA damage response; kaposi; sarcoma; tumor; skin; cancer DNA damage response; kaposi; sarcoma; tumor; skin; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Di Domenico, E.G.; Toma, L.; Bordignon, V.; Trento, E.; D’Agosto, G.; Cordiali-Fei, P.; Ensoli, F. Activation of DNA Damage Response Induced by the Kaposi’s Sarcoma-Associated Herpes Virus. Int. J. Mol. Sci. 2016, 17, 854.

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