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Int. J. Mol. Sci. 2016, 17(6), 808; doi:10.3390/ijms17060808

The Protective Effect of Grape-Seed Proanthocyanidin Extract on Oxidative Damage Induced by Zearalenone in Kunming Mice Liver

1
Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
2
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
These authors contributed equally to this study.
*
Authors to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 11 April 2016 / Revised: 30 April 2016 / Accepted: 11 May 2016 / Published: 25 May 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [2227 KB, uploaded 25 May 2016]   |  

Abstract

Although grape-seed proanthocyanidin extract (GSPE) demonstrates strong anti-oxidant activity, little research has been done to clearly reveal the protective effects on the hepatotoxicity caused by zearalenone (ZEN). This study is to explore the protective effect of GSPE on ZEN-induced oxidative damage of liver in Kunming mice and the possible protective molecular mechanism of GSPE. The results indicated that GSPE could greatly reduce the ZEN-induced increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities. GSPE also significantly decreased the content of MDA but enhanced the activities of antioxidant enzymes SOD and GSH-Px. The analysis indicated that ZEN decreased both mRNA expression levels and protein expression levels of nuclear erythroid2-related factor2 (Nrf2). Nrf2 is considered to be an essential antioxidative transcription factor, as downstream GSH-Px, γ-glutamyl cysteine synthetase (γ-GCS), hemeoxygenase-1 (HO-1), and quinone oxidoreductase 1 (NQO1) decreased simultaneously, whereas the pre-administration of GSPE groups was shown to elevate these expressions. The results indicated that GSPE exerted a protective effect on ZEN-induced hepatic injury and the mechanism might be related to the activation of the Nrf2/ARE signaling pathway. View Full-Text
Keywords: grape seed proanthocyanidin extract; zearalenone; oxidative damage; Nrf2/ARE pathway; liver; mice grape seed proanthocyanidin extract; zearalenone; oxidative damage; Nrf2/ARE pathway; liver; mice
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Long, M.; Yang, S.-H.; Han, J.-X.; Li, P.; Zhang, Y.; Dong, S.; Chen, X.; Guo, J.; Wang, J.; He, J.-B. The Protective Effect of Grape-Seed Proanthocyanidin Extract on Oxidative Damage Induced by Zearalenone in Kunming Mice Liver. Int. J. Mol. Sci. 2016, 17, 808.

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