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Int. J. Mol. Sci. 2016, 17(6), 807; doi:10.3390/ijms17060807

Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury

1
Experimental Pathology Department, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council (IIBB-CSIC), Rosselló 161, 08036-Barcelona, Catalonia, Spain
2
Department of Medicine, LaBioMed at Harbor UCLA Medical Center, Torrance, 90502 CA, USA
3
Centre Hépatobiliaire, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, 75008 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editor: Masato Matsuoka
Received: 24 April 2016 / Revised: 15 May 2016 / Accepted: 17 May 2016 / Published: 25 May 2016
(This article belongs to the Special Issue Modulators of Endoplasmic Reticulum Stress)
View Full-Text   |   Download PDF [497 KB, uploaded 25 May 2016]   |  

Abstract

The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic reticulum stress (ERS). This can be triggered by many physiopathological conditions such as alcoholic steatohepatitis, insulin resistance or ischemia-reperfusion injury. The cell reacts to ERS by initiating a defensive process known as the unfolded protein response (UPR), which comprises cellular mechanisms for adaptation and the safeguarding of cell survival or, in cases of excessively severe stress, for the initiation of the cell death program. Recent experimental data suggest the involvement of ERS in ischemia/reperfusion injury (IRI) of the liver graft, which has been considered as one of major problems influencing outcome after liver transplantation. The purpose of this review is to summarize updated data on the molecular mechanisms of ERS/UPR and the consequences of this pathology, focusing specifically on solid organ preservation and liver transplantation models. We will also discuss the potential role of ERS, beyond the simple adaptive response and the regulation of cell death, in the modification of cell functional properties and phenotypic changes. View Full-Text
Keywords: endoplasmic reticulum stress; unfolded protein response; liver ischemia reperfusion injury; orthotopic liver transplantation; University Wisconsin (UW) solution; Institut Georges Lopez-1 (IGL-1) solution endoplasmic reticulum stress; unfolded protein response; liver ischemia reperfusion injury; orthotopic liver transplantation; University Wisconsin (UW) solution; Institut Georges Lopez-1 (IGL-1) solution
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Folch-Puy, E.; Panisello, A.; Oliva, J.; Lopez, A.; Castro Benítez, C.; Adam, R.; Roselló-Catafau, J. Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury. Int. J. Mol. Sci. 2016, 17, 807.

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