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Int. J. Mol. Sci. 2016, 17(6), 700; doi:10.3390/ijms17060700

Pesticides Drive Stochastic Changes in the Chemoreception and Neurotransmission System of Marine Ectoparasites

Laboratory of Biotechnology and Aquatic Genomics, Interdisciplinary Center for Aquaculture Research, Department of Oceanography, Universidad de Concepción, Concepción 4030000, Chile
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Academic Editor: Katalin Prokai-Tatrai
Received: 6 April 2016 / Revised: 30 April 2016 / Accepted: 4 May 2016 / Published: 31 May 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Scientific efforts to elucidate the mechanisms of chemical communication between organisms in marine environments are increasing. This study applied novel molecular technology to outline the effects of two xenobiotic drugs, deltamethrin (DM) and azamethiphos (AZA), on the neurotransmission system of the copepod ectoparasite Caligus rogercresseyi. Transcriptome sequencing and bioinformatics analyses were conducted to evaluate treatment effects on the glutamatergic synaptic pathway of the parasite, which is closely related to chemoreception and neurotransmission. After drug treatment with DM or AZA, stochastic mRNA expression patterns of glutamatergic synapse pathway components were observed. Both DM and AZA promoted a down-regulation of the glutamate-ammonia ligase, and DM activated a metabotropic glutamate receptor that is a suggested inhibitor of neurotransmission. Furthermore, the delousing drugs drove complex rearrangements in the distribution of mapped reads for specific metabotropic glutamate receptor domains. This study introduces a novel methodological approach that produces high-quality results from transcriptomic data. Using this approach, DM and AZA were found to alter the expression of numerous mRNAs tightly linked to the glutamatergic signaling pathway. These data suggest possible new targets for xenobiotic drugs that play key roles in the delousing effects of antiparasitics in sea lice. View Full-Text
Keywords: Caligus rogercresseyi; sea lice; deltamethrin; azamethiphos; glutamatergic synapse; metabotropic receptor; ionotropic receptor Caligus rogercresseyi; sea lice; deltamethrin; azamethiphos; glutamatergic synapse; metabotropic receptor; ionotropic receptor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Núñez-Acuña, G.; Boltaña, S.; Gallardo-Escárate, C. Pesticides Drive Stochastic Changes in the Chemoreception and Neurotransmission System of Marine Ectoparasites. Int. J. Mol. Sci. 2016, 17, 700.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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