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Int. J. Mol. Sci. 2016, 17(5), 790; doi:10.3390/ijms17050790

Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types

1
Pathology Unit, Istituto Nazionale Tumori Fondazione “G. Pascale”, via Mariano Semmola, 80131 Napoli, Italy
2
Molecular Immunology and Immunoregulation Functional Genomics, Istituto Nazionale Tumori Fondazione “G. Pascale”, via Mariano Semmola, 80131 Napoli, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 12 April 2016 / Revised: 12 May 2016 / Accepted: 16 May 2016 / Published: 21 May 2016
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Abstract

In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate with a poor prognosis of patients with several types of cancer. However, recent reports have revealed that the immunohistochemical (IHC) expression of the PD-L1 in tumor cells is not uniform for the use of different antibodies clones, with variable specificity, often doubtful topographical localization, and with a score not uniquely defined. The purpose of this study was to analyze the IHC expression of PD-L1 on a large series of several human tumors to correctly define its staining in different tumor tissues. View Full-Text
Keywords: PD-L1; immunohistochemical staining; tissue type’s variability PD-L1; immunohistochemical staining; tissue type’s variability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Scognamiglio, G.; De Chiara, A.; Di Bonito, M.; Tatangelo, F.; Losito, N.S.; Anniciello, A.; De Cecio, R.; D’Alterio, C.; Scala, S.; Cantile, M.; Botti, G. Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types. Int. J. Mol. Sci. 2016, 17, 790.

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