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Int. J. Mol. Sci. 2016, 17(5), 763; doi:10.3390/ijms17050763

The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation

1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Department of Chest Medicine, Cheng-Ching General Hospital, Taichung 402, Taiwan
3
Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
4
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
5
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan
6
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
7
Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
8
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 6 April 2016 / Revised: 6 May 2016 / Accepted: 16 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue Big Data for Oncology)
View Full-Text   |   Download PDF [214 KB, uploaded 18 May 2016]

Abstract

The insulin-like growth factor 1 (IGF1) signaling pathway mediates multiple cancer cell biological processes. IGF1 receptor (IGF1R) expression has been used as a reporter of the clinical significance of non-small-cell lung carcinoma (NSCLC). However, the association between IGF1R genetic variants and the clinical utility of NSCLC positive for epidermal growth factor receptor (EGFR) mutation is not clear. The current study investigated the association between the IGF1R genetic variants, the occurrence of EGFR mutations, and clinicopathological characteristics in NSCLC patients. A total of 452 participants, including 362 adenocarcinoma lung cancer and 90 squamous cell carcinoma lung cancer patients, were selected for analysis of IGF1R genetic variants (rs7166348, rs2229765, and rs8038415) using real-time polymerase chain reaction (PCR)genotyping. The results indicated that GA + AA genotypes of IGF1R rs2229765 were significantly associated with EGFR mutation in female lung adenocarcinoma patients (odds ratio (OR) = 0.39, 95% confidence interval (CI) = 0.17–0.87). Moreover, The GA + AA genotype IGF1R rs2229765 was significantly associated with EGFR L858R mutation (p = 0.02) but not with the exon 19 in-frame deletion. Furthermore, among patients without EGFR mutation, those who have at least one polymorphic A allele of IGF1R rs7166348 have an increased incidence of lymph node metastasis when compared with those patients homozygous for GG (OR, 2.75; 95% CI, 1.20–2.31). Our results showed that IGF1R genetic variants are related to EGFR mutation in female lung adenocarcinoma patients and may be a predictive factor for tumor lymph node metastasis in Taiwanese patients with NSCLC. View Full-Text
Keywords: non-small-cell lung carcinoma; insulin-like growth factor 1 receptor; epidermal growth factor receptor; genetic variants non-small-cell lung carcinoma; insulin-like growth factor 1 receptor; epidermal growth factor receptor; genetic variants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, T.-C.; Hsieh, M.-J.; Liu, M.-C.; Chiang, W.-L.; Tsao, T.C.-Y.; Yang, S.-F. The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation. Int. J. Mol. Sci. 2016, 17, 763.

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