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Int. J. Mol. Sci. 2016, 17(5), 716; doi:10.3390/ijms17050716

MicroRNA in United Airway Diseases

1
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clinic, University of Barcelona & Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Barcelona 08036, Catalonia, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 1 April 2016 / Revised: 2 May 2016 / Accepted: 5 May 2016 / Published: 12 May 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [618 KB, uploaded 12 May 2016]   |  

Abstract

The concept of united airway diseases (UAD) has received increasing attention in recent years. Sustained and increased inflammation is a common feature of UAD, which is inevitably accompanied with marked gene modification and tight gene regulation. However, gene regulation in the common inflammatory processes in UAD remains unclear. MicroRNA (miRNA), a novel regulator of gene expression, has been considered to be involved in many inflammatory diseases. Although there are an increasing number of studies of miRNAs in inflammatory upper and lower airway diseases, few miRNAs have been identified that directly link the upper and lower airways. In this article, therefore, we reviewed the relevant studies available in order to improve the understanding of the roles of miRNAs in the interaction and pathogenesis of UAD. View Full-Text
Keywords: united airways disease; microRNA; inflammation; allergic rhinitis; rhinosinusitis; asthma united airways disease; microRNA; inflammation; allergic rhinitis; rhinosinusitis; asthma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, Z.; Zhang, X.-H.; Callejas-Díaz, B.; Mullol, J. MicroRNA in United Airway Diseases. Int. J. Mol. Sci. 2016, 17, 716.

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