Next Article in Journal
Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma
Next Article in Special Issue
Fast Modeling of Binding Affinities by Means of Superposing Significant Interaction Rules (SSIR) Method
Previous Article in Journal
The Establishment of an Assay to Measure DNA Polymerase-Catalyzed Repair of UVB-Induced DNA Damage in Skin Cells and Screening of DNA Polymerase Enhancers from Medicinal Plants
Previous Article in Special Issue
3D-QSAR Studies on Barbituric Acid Derivatives as Urease Inhibitors and the Effect of Charges on the Quality of a Model
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(5), 666; doi:10.3390/ijms17050666

A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines

1
Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata 700068, India
2
Natural Resources Research Institute and Department of Chemistry & Biochemistry, University of Minnesota Duluth, Duluth, MN 55811, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Humberto Gonzalez-Diaz, Roberto Todeschini and Alejandro Pazos Sierra
Received: 1 April 2016 / Revised: 25 April 2016 / Accepted: 27 April 2016 / Published: 4 May 2016
View Full-Text   |   Download PDF [363 KB, uploaded 4 May 2016]   |  

Abstract

The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development. View Full-Text
Keywords: peptide vaccines; computer assisted vaccine development; epitopes; alignment-free analysis; web based approaches; sequence descriptors; rational peptide vaccine design; dengue; chikungunya; rotavirus; Zika virus peptide vaccines; computer assisted vaccine development; epitopes; alignment-free analysis; web based approaches; sequence descriptors; rational peptide vaccine design; dengue; chikungunya; rotavirus; Zika virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nandy, A.; Basak, S.C. A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines. Int. J. Mol. Sci. 2016, 17, 666.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top