The Dark Side of Cell Fusion
AbstractCell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy. View Full-Text
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Bastida-Ruiz, D.; Van Hoesen, K.; Cohen, M. The Dark Side of Cell Fusion. Int. J. Mol. Sci. 2016, 17, 638.
Bastida-Ruiz D, Van Hoesen K, Cohen M. The Dark Side of Cell Fusion. International Journal of Molecular Sciences. 2016; 17(5):638.Chicago/Turabian Style
Bastida-Ruiz, Daniel; Van Hoesen, Kylie; Cohen, Marie. 2016. "The Dark Side of Cell Fusion." Int. J. Mol. Sci. 17, no. 5: 638.
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