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Int. J. Mol. Sci. 2016, 17(5), 625; doi:10.3390/ijms17050625

KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions

1
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan
2
Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: William Chi-shing Cho and Kwong-Kwok Wong
Received: 11 November 2015 / Revised: 10 March 2016 / Accepted: 20 April 2016 / Published: 26 April 2016
(This article belongs to the Collection Advances in Molecular Oncology)
View Full-Text   |   Download PDF [2379 KB, uploaded 26 April 2016]   |  

Abstract

Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression. View Full-Text
Keywords: low-grade serous carcinoma; KRAS ; BRAF ; mutation low-grade serous carcinoma; KRAS ; BRAF ; mutation
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Nakamura, K.; Nakayama, K.; Ishibashi, T.; Ishikawa, N.; Ishikawa, M.; Katagiri, H.; Minamoto, T.; Sato, E.; Sanuki, K.; Yamashita, H.; Iida, K.; Sultana, R.; Kyo, S. KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions. Int. J. Mol. Sci. 2016, 17, 625.

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