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Int. J. Mol. Sci. 2016, 17(5), 625; doi:10.3390/ijms17050625

KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions

Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan
Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan
Author to whom correspondence should be addressed.
Academic Editors: William Chi-shing Cho and Kwong-Kwok Wong
Received: 11 November 2015 / Revised: 10 March 2016 / Accepted: 20 April 2016 / Published: 26 April 2016
(This article belongs to the Collection Advances in Molecular Oncology)
View Full-Text   |   Download PDF [2379 KB, uploaded 26 April 2016]   |  


Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression. View Full-Text
Keywords: low-grade serous carcinoma; KRAS ; BRAF ; mutation low-grade serous carcinoma; KRAS ; BRAF ; mutation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nakamura, K.; Nakayama, K.; Ishibashi, T.; Ishikawa, N.; Ishikawa, M.; Katagiri, H.; Minamoto, T.; Sato, E.; Sanuki, K.; Yamashita, H.; Iida, K.; Sultana, R.; Kyo, S. KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions. Int. J. Mol. Sci. 2016, 17, 625.

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