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Int. J. Mol. Sci. 2016, 17(5), 621; doi:10.3390/ijms17050621

Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer

1
School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
2
Department of Dermatology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Elma Baron
Received: 1 March 2016 / Revised: 11 April 2016 / Accepted: 14 April 2016 / Published: 26 April 2016
(This article belongs to the Special Issue Sleep, Circadian Rhythm and Skin)
View Full-Text   |   Download PDF [609 KB, uploaded 26 April 2016]   |  

Abstract

Circadian rhythms are core regulators of a variety of mammalian physiologic processes and oscillate in a 24-h pattern. Many peripheral organs possess endogenous rhythmicity that is then modulated by a master clock; the skin is one of these peripheral organs. The dysregulation of rhythms is associated with decreased ability to ameliorate cellular stressors at a local and global level, which then increases the propensity for the development of neoplastic growths. In this article, we review the implications of altered circadian rhythms on DNA repair as well as modified gene expression of core clock proteins with particular focus on skin models. These findings are then correlated with epidemiologic data regarding skin cancer to showcase the effects of circadian disruption on this phenomenon. View Full-Text
Keywords: circadian rhythms; skin cancer; melatonin; UVR; epidemiology circadian rhythms; skin cancer; melatonin; UVR; epidemiology
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Gutierrez, D.; Arbesman, J. Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer. Int. J. Mol. Sci. 2016, 17, 621.

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