Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action
AbstractCancer, being the second leading cause of mortality, exists as a formidable health challenge. In spite of our enormous efforts, the emerging complexities in the molecular nature of disease progression limit the real success in finding an effective cancer cure. It is now conceivable that cancer is, in fact, a progressive illness, and the morbidity and mortality from cancer can be reduced by interfering with various oncogenic signaling pathways. A wide variety of structurally diverse classes of bioactive phytochemicals have been shown to exert anticancer effects in a large number of preclinical studies. Multiple lines of evidence suggest that withaferin-A can prevent the development of cancers of various histotypes. Accumulating data from different rodent models and cell culture experiments have revealed that withaferin-A suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, anti-proliferative and apoptosis-inducing properties. Moreover, withaferin-A sensitizes resistant cancer cells to existing chemotherapeutic agents. The purpose of this review is to highlight the mechanistic aspects underlying anticancer effects of withaferin-A. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lee, I.-C.; Choi, B.Y. Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action. Int. J. Mol. Sci. 2016, 17, 290.
Lee I-C, Choi BY. Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action. International Journal of Molecular Sciences. 2016; 17(3):290.Chicago/Turabian Style
Lee, In-Chul; Choi, Bu Y. 2016. "Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action." Int. J. Mol. Sci. 17, no. 3: 290.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.