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Int. J. Mol. Sci. 2016, 17(2), 238; doi:10.3390/ijms17020238

The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
Department of Pharmacy, Logistics College of Chinese People’s Armed Police Force, Tianjin 300309, China
3
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 6 January 2016 / Revised: 3 February 2016 / Accepted: 4 February 2016 / Published: 15 February 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [5669 KB, uploaded 15 February 2016]   |  

Abstract

Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicine, has a prominent anti-inflammatory effect. The present study is to explore the inhibitory effects of mKG on bleomycin (BLM)-induced pulmonary fibrosis in mice. mKG significantly decreased pulmonary alveolitis, fibrosis scores, and interleukin-6 (IL-6), interleukin-17 (IL-17), transforming growth factor-β (TGF-β) and hydroxyproline (HYP) levels in lung tissue of mice compared with BLM treatment. It markedly alleviated the increase of HYP content in the lung tissues and pathologic changes of pulmonary fibrosis caused by BLM instillation. In conclusion, mKG has an anti-fibrotic effect and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis. View Full-Text
Keywords: pulmonary fibrosis; bleomycin; mKG (Modified Kushen Gancao Formula); mice pulmonary fibrosis; bleomycin; mKG (Modified Kushen Gancao Formula); mice
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, Y.; Yao, L.-F.; Zhao, Y.; Wei, L.-M.; Guo, P.; Yu, M.; Cao, B.; Li, T.; Chen, H.; Zou, Z.-M. The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin. Int. J. Mol. Sci. 2016, 17, 238.

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