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Int. J. Mol. Sci. 2016, 17(2), 201; doi:10.3390/ijms17020201

Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States

University of North Carolina Liver Center, 8011 Burnett-Womack Building, Chapel Hill, NC 27599-8754, USA
Academic Editor: Rolf Teschke
Received: 10 January 2016 / Revised: 27 January 2016 / Accepted: 28 January 2016 / Published: 4 February 2016
(This article belongs to the Special Issue Drug, Herb, and Dietary Supplement Hepatotoxicity)
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Abstract

Hepatotoxicity due to drugs, herbal or dietary supplements remains largely a clinical diagnosis based on meticulous history taking and exclusion of other causes of liver injury. In 2004, the U.S. Drug-Induced Liver Injury Network (DILIN) was created under the auspices of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases with the aims of establishing a large registry of cases for clinical, epidemiological and mechanistic study. From inception, the DILIN has used an expert opinion process that incorporates consensus amongst three different DILIN hepatologists assigned to each case. It is the most well-established, well-described and vigorous expert opinion process for DILI to date, and yet it is an imperfect standard. This review will discuss the DILIN expert opinion process, its strengths and weaknesses, psychometric performance and future. View Full-Text
Keywords: hepatotoxicity; causality; diagnosis; expert opinion hepatotoxicity; causality; diagnosis; expert opinion
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Hayashi, P.H. Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States. Int. J. Mol. Sci. 2016, 17, 201.

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