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Int. J. Mol. Sci. 2016, 17(2), 166; doi:10.3390/ijms17020166

Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, Blg G/E CP 611, Brussels B-1070, Belgium
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Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 16 December 2015 / Revised: 20 January 2016 / Accepted: 21 January 2016 / Published: 27 January 2016
(This article belongs to the Special Issue Aquaporin)
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Abstract

Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and is pointing out possible difference between major salivary glands, i.e., parotid, submandibular and sublingual glands. View Full-Text
Keywords: aquaporin; expression; saliva secretion; salivary gland; subcellular localization; pathophysiology; physiology aquaporin; expression; saliva secretion; salivary gland; subcellular localization; pathophysiology; physiology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Delporte, C.; Bryla, A.; Perret, J. Aquaporins in Salivary Glands: From Basic Research to Clinical Applications. Int. J. Mol. Sci. 2016, 17, 166.

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