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Int. J. Mol. Sci. 2016, 17(2), 149; doi:10.3390/ijms17020149

Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities

1
Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, Brazil
2
Unidade Integrada de Farmacologia e Gastroenterologia, Faculdade de Ciências Médicas, Universidade São Francisco, CEP 12916-900 Bragança Paulista, São Paulo, Brazil
3
Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, Brazil
4
Departamento de Ciências Biológicas, Faculdade de Ciências, Universidade Estadual Paulista—UNESP, CEP 17033-360 Bauru, São Paulo, Brazil
5
Departamento de Botânica, Instituto de Biociências, Universidade Estadual Paulista—UNESP, CEP 18618-970 Botucatu, São Paulo, Brazil
6
Campus Experimental do Litoral Paulista, Universidade Estadual Paulista-UNESP, CEP 11330-900 São Vicente, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 30 October 2015 / Revised: 21 December 2015 / Accepted: 22 December 2015 / Published: 23 January 2016
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2016)
View Full-Text   |   Download PDF [1558 KB, uploaded 23 January 2016]   |  

Abstract

The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit. View Full-Text
Keywords: Cissus sicyoides; Vitaceae; anti-inflammatory; PGE2; antidiarrheal Cissus sicyoides; Vitaceae; anti-inflammatory; PGE2; antidiarrheal
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MDPI and ACS Style

Beserra, F.P.; de Cássia Santos, R.; Périco, L.L.; Rodrigues, V.P.; de Almeida Kiguti, L.R.; Saldanha, L.L.; Pupo, A.S.; da Rocha, L.R.M.; Dokkedal, A.L.; Vilegas, W.; Hiruma-Lima, C.A. Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities. Int. J. Mol. Sci. 2016, 17, 149.

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