Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities
AbstractThe objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit. View Full-Text
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Beserra, F.P.; de Cássia Santos, R.; Périco, L.L.; Rodrigues, V.P.; de Almeida Kiguti, L.R.; Saldanha, L.L.; Pupo, A.S.; da Rocha, L.R.M.; Dokkedal, A.L.; Vilegas, W.; Hiruma-Lima, C.A. Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities. Int. J. Mol. Sci. 2016, 17, 149.
Beserra FP, de Cássia Santos R, Périco LL, Rodrigues VP, de Almeida Kiguti LR, Saldanha LL, Pupo AS, da Rocha LRM, Dokkedal AL, Vilegas W, Hiruma-Lima CA. Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities. International Journal of Molecular Sciences. 2016; 17(2):149.Chicago/Turabian Style
Beserra, Fernando P.; de Cássia Santos, Raquel; Périco, Larissa L.; Rodrigues, Vinicius P.; de Almeida Kiguti, Luiz R.; Saldanha, Luiz L.; Pupo, André S.; da Rocha, Lúcia R.M.; Dokkedal, Anne L.; Vilegas, Wagner; Hiruma-Lima, Clélia A. 2016. "Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities." Int. J. Mol. Sci. 17, no. 2: 149.
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