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Int. J. Mol. Sci. 2016, 17(12), 2143; doi:10.3390/ijms17122143

Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein

1
Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan
2
Department of Hepatology, East Shonan General Hospital, Kanagawa 253-0083, Japan
3
Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan
4
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo 113-8431, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Tatsuo Kanda and William Chi-shing Cho
Received: 12 October 2016 / Revised: 30 November 2016 / Accepted: 14 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Hepatitis Virus Infection and Research)
View Full-Text   |   Download PDF [1589 KB, uploaded 20 December 2016]   |  

Abstract

We aimed to clarify the association between a novel serum fibrosis marker, Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP), and hepatocellular carcinoma (HCC) development in 355 patients with chronic hepatitis C who achieved sustained virologic response (SVR) through interferon-based antiviral therapy. Pretreatment serum WFA+-M2BP levels were quantified and the hazard ratios (HRs) for HCC development were retrospectively analyzed by Cox proportional hazard analysis. During the median follow-up time of 2.9 years, 12 patients developed HCC. Multivariate analysis demonstrated that high serum WFA+-M2BP (≥2.80 cut off index (COI), HR = 15.20, p = 0.013) and high fibrosis-4 (FIB-4) index (≥3.7, HR = 5.62, p = 0.034) were independent risk factors for HCC development. The three- and five-year cumulative incidence of HCC in patients with low WFA+-M2BP were 0.4% and 0.4%, respectively, whereas those of patients with high WFA+-M2BP were 7.7% and 17.6%, respectively (p < 0.001). In addition, combination of serum WFA+-M2BP and FIB-4 indices successfully stratified the risk of HCC: the five-year cumulative incidences of HCC were 26.9%, 6.8%, and 0.0% in patients with both, either, and none of these risk factors, respectively (p < 0.001). In conclusion, pretreatment serum WFA+-M2BP level is a useful predictor for HCC development after achieving SVR. View Full-Text
Keywords: WFA+-M2BP; hepatocellular carcinoma; chronic hepatitis C; risk factor; sustained virological response WFA+-M2BP; hepatocellular carcinoma; chronic hepatitis C; risk factor; sustained virological response
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MDPI and ACS Style

Sato, S.; Genda, T.; Ichida, T.; Amano, N.; Sato, S.; Murata, A.; Tsuzura, H.; Narita, Y.; Kanemitsu, Y.; Hirano, K.; Shimada, Y.; Iijima, K.; Wada, R.; Nagahara, A.; Watanabe, S. Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein. Int. J. Mol. Sci. 2016, 17, 2143.

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