Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers
AbstractPromising targeted therapy and personalized medicine are making molecular profiling of tumours a priority. For colorectal cancer (CRC) patients, international guidelines made RAS (KRAS and NRAS) status a prerequisite for the use of anti-epidermal growth factor receptor agents (anti-EGFR). Daily, new data emerge on the theranostic and prognostic role of molecular biomarkers, which is a strong incentive for a validated, sensitive and broadly available molecular screening test in order to implement and improve multi-modal therapy strategy and clinical trials. Next generation sequencing (NGS) has begun to supplant other technologies for genomic profiling. Targeted NGS is a method that allows parallel sequencing of thousands of short DNA sequences in a single test offering a cost-effective approach for detecting multiple genetic alterations with a minimum amount of DNA. In the present review, we collected data concerning the clinical application of NGS technology in the setting of colorectal cancer. View Full-Text
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Fontanges, Q.; De Mendonca, R.; Salmon, I.; Le Mercier, M.; D’Haene, N. Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers. Int. J. Mol. Sci. 2016, 17, 2117.
Fontanges Q, De Mendonca R, Salmon I, Le Mercier M, D’Haene N. Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers. International Journal of Molecular Sciences. 2016; 17(12):2117.Chicago/Turabian Style
Fontanges, Quitterie; De Mendonca, Ricardo; Salmon, Isabelle; Le Mercier, Marie; D’Haene, Nicky. 2016. "Clinical Application of Targeted Next Generation Sequencing for Colorectal Cancers." Int. J. Mol. Sci. 17, no. 12: 2117.
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