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Int. J. Mol. Sci. 2016, 17(12), 2082; doi:10.3390/ijms17122082

Pathophysiology of Non Alcoholic Fatty Liver Disease

1
Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy
2
Cardiometabolic Risk Unit—Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy
3
Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy
4
Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy
5
Department of Nephrology, Urology and Renal Transplant—Fondazione IRCCS Ca’, Granda, PC 20122 Milano, Italy
6
Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy
7
Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy
8
Metabolic Liver Diseases—Università degli Studi Milano-Fondazione IRCCS Ca’, Granda via F Sforza 35, PC 20122 Milano, Italy
9
Institute for Health, PC 53042, Chianciano Terme, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 22 September 2016 / Revised: 30 November 2016 / Accepted: 1 December 2016 / Published: 11 December 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
View Full-Text   |   Download PDF [516 KB, uploaded 13 December 2016]   |  

Abstract

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation. View Full-Text
Keywords: fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P fatty liver; insulin resistance; free fatty acids; cholesterol; adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1; ghrelin; irisin; selenoprotein P
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MDPI and ACS Style

Petta, S.; Gastaldelli, A.; Rebelos, E.; Bugianesi, E.; Messa, P.; Miele, L.; Svegliati-Baroni, G.; Valenti, L.; Bonino, F. Pathophysiology of Non Alcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2016, 17, 2082.

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