Next Article in Journal
HER2 Analysis in Sporadic Thyroid Cancer of Follicular Cell Origin
Next Article in Special Issue
Toll Like Receptor 2, 4, and 9 Signaling Promotes Autoregulative Tumor Cell Growth and VEGF/PDGF Expression in Human Pancreatic Cancer
Previous Article in Journal
The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis
Previous Article in Special Issue
Meta-Analysis of Early Nutrition: The Benefits of Enteral Feeding Compared to a Nil Per Os Diet Not Only in Severe, but Also in Mild and Moderate Acute Pancreatitis
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(12), 2038; doi:10.3390/ijms17122038

Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis

1
Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland
2
Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland
3
Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland
4
Department of Diagnostics, University Hospital, 31-501 Kraków, Poland
5
Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland
6
Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland
7
Department of Theory of Sport and Kinesiology, Faculty of Physical Education and Sport, University of Physical Education, 31-571 Kraków, Poland
8
Department of Pharmacology, Jagiellonian University Medical College, 31-531 Kraków, Poland
9
Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Srikumar Chellappan
Received: 1 October 2016 / Revised: 23 November 2016 / Accepted: 30 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Pancreatic Disorders)
View Full-Text   |   Download PDF [1149 KB, uploaded 6 December 2016]   |  

Abstract

Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay. Serum concentrations of sFlt-1 were significantly higher in patients with MSAP and SAP as compared to MAP. SAP patients had the highest concentrations. At 24 and 48 h, sFlt-1 positively correlated with inflammatory markers (leukocyte count, C-reactive protein), kidney function (creatinine, urea, cystatin C, serum and urine neutrophil gelatinase-associated lipocalin, urine albumin/creatinine ratio), D-dimer and angiopoietin-2. sFlt-1 positively correlated with the bedside index of severity in AP (BISAP) score and the duration of hospital stay. Serum sFlt-1 above 139 pg/mL predicted more severe AP (MSAP + SAP). In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity. View Full-Text
Keywords: vascular endothelial growth factor receptor 1; acute pancreatitis; endothelial dysfunction; angiopoietin-2; diagnostic utility vascular endothelial growth factor receptor 1; acute pancreatitis; endothelial dysfunction; angiopoietin-2; diagnostic utility
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dumnicka, P.; Sporek, M.; Mazur-Laskowska, M.; Ceranowicz, P.; Kuźniewski, M.; Drożdż, R.; Ambroży, T.; Olszanecki, R.; Kuśnierz-Cabala, B. Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis. Int. J. Mol. Sci. 2016, 17, 2038.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top