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Int. J. Mol. Sci. 2016, 17(12), 2028; doi:10.3390/ijms17122028

Exosomes as miRNA Carriers: Formation–Function–Future

1
Institute for Pathology, University Hospital of Cologne, 50924 Cologne, Germany
2
Center for Molecular Medicine Cologne, University of Cologne, 50924 Cologne, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Gregor Drummen and Suresh Mathivanan
Received: 9 August 2016 / Revised: 25 November 2016 / Accepted: 30 November 2016 / Published: 2 December 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
View Full-Text   |   Download PDF [725 KB, uploaded 2 December 2016]   |  

Abstract

Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine. View Full-Text
Keywords: extracellular vesicle; exosome; cell metabolism; miRNA extracellular vesicle; exosome; cell metabolism; miRNA
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Yu, X.; Odenthal, M.; Fries, J.W.U. Exosomes as miRNA Carriers: Formation–Function–Future. Int. J. Mol. Sci. 2016, 17, 2028.

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