Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk
AbstractSolid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate the molecular secondary structure of poly(Gly-Gly-X), which is one of the most common structural repetitive motifs found in orb-weaving dragline spider silk proteins. The combination of NMR and computational experiments provides insight into the molecular secondary structure of poly(Gly-Gly-X) segments and provides further support that these regions are disordered and primarily non-β-sheet. Furthermore, the combination of NMR and MD simulations illustrate the possibility for several secondary structural elements in the poly(Gly-Gly-X) regions of dragline silks, including β-turns, 310-helicies, and coil structures with a negligible population of α-helix observed. View Full-Text
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Gray, G.M.; van der Vaart, A.; Guo, C.; Jones, J.; Onofrei, D.; Cherry, B.R.; Lewis, R.V.; Yarger, J.L.; Holland, G.P. Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk. Int. J. Mol. Sci. 2016, 17, 2023.
Gray GM, van der Vaart A, Guo C, Jones J, Onofrei D, Cherry BR, Lewis RV, Yarger JL, Holland GP. Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk. International Journal of Molecular Sciences. 2016; 17(12):2023.Chicago/Turabian Style
Gray, Geoffrey M.; van der Vaart, Arjan; Guo, Chengchen; Jones, Justin; Onofrei, David; Cherry, Brian R.; Lewis, Randolph V.; Yarger, Jeffery L.; Holland, Gregory P. 2016. "Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk." Int. J. Mol. Sci. 17, no. 12: 2023.
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