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Int. J. Mol. Sci. 2016, 17(12), 2012; doi:10.3390/ijms17122012

Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release

1
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
2
College of Chemistry and Chemical Engineering and Biological Engineering, Donghua University, Shanghai 201620, China
3
Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India
*
Author to whom correspondence should be addressed.
Academic Editors: John G. Hardy and Chris Holland
Received: 12 October 2016 / Revised: 25 November 2016 / Accepted: 26 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
View Full-Text   |   Download PDF [3415 KB, uploaded 1 December 2016]   |  

Abstract

Natural silk protein nanoparticles are a promising biomaterial for drug delivery due to their pleiotropic properties, including biocompatibility, high bioavailability, and biodegradability. Chinese oak tasar Antheraea pernyi silk fibroin (ApF) nanoparticles are easily obtained using cations as reagents under mild conditions. The mild conditions are potentially advantageous for the encapsulation of sensitive drugs and therapeutic molecules. In the present study, silk fibroin protein nanoparticles are loaded with differently-charged small-molecule drugs, such as doxorubicin hydrochloride, ibuprofen, and ibuprofen-Na, by simple absorption based on electrostatic interactions. The structure, morphology and biocompatibility of the silk nanoparticles in vitro are investigated. In vitro release of the drugs from the nanoparticles depends on charge-charge interactions between the drugs and the nanoparticles. The release behavior of the compounds from the nanoparticles demonstrates that positively-charged molecules are released in a more prolonged or sustained manner. Cell viability studies with L929 demonstrated that the ApF nanoparticles significantly promoted cell growth. The results suggest that Chinese oak tasar Antheraea pernyi silk fibroin nanoparticles can be used as an alternative matrix for drug carrying and controlled release in diverse biomedical applications. View Full-Text
Keywords: Antheraea pernyi silk fibroin; nanoparticles; controlled drug release Antheraea pernyi silk fibroin; nanoparticles; controlled drug release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, J.; Yin, Z.; Xue, X.; Kundu, S.C.; Mo, X.; Lu, S. Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release. Int. J. Mol. Sci. 2016, 17, 2012.

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