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Int. J. Mol. Sci. 2016, 17(12), 2002; doi:10.3390/ijms17122002

Autoimmune Regulator Expression in DC2.4 Cells Regulates the NF-κB Signaling and Cytokine Expression of the Toll-Like Receptor 3 Pathway

Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 22 July 2016 / Revised: 18 November 2016 / Accepted: 24 November 2016 / Published: 1 December 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Autoimmune regulator (Aire) mutations result in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), which manifests as multi-organ autoimmunity and chronic mucocutaneous candidiasis (CMC). Indendritic cells (DCs), pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), are closely involved in the recognition of various pathogens, activating the intercellular signaling pathway, followed by the activation of transcription factors and the expression of downstream genes, which take part in mediating the immune response and maintaining immune tolerance. In this study, we found that Aire up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-κB (NF-κB) of the TLR3 signaling pathway. View Full-Text
Keywords: autoimmune regulator; immune tolerance; TLR3 autoimmune regulator; immune tolerance; TLR3
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, J.; Niu, K.; Fu, H.; Li, H.; Li, Y.; Yang, W. Autoimmune Regulator Expression in DC2.4 Cells Regulates the NF-κB Signaling and Cytokine Expression of the Toll-Like Receptor 3 Pathway. Int. J. Mol. Sci. 2016, 17, 2002.

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