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Int. J. Mol. Sci. 2016, 17(12), 1908; doi:10.3390/ijms17121908

Histone H3 Methyltransferase Suv39h1 Prevents Myogenic Terminal Differentiation by Repressing MEF2 Activity in Muscle Cells

1
,
1
,
2,†
and
1,3,†,*
1
Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture & Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China
2
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
3
Key Projects in the Cooperative Innovation Center for Sustainable Pig Production of Wuhan, Wuhan 430070, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: David Sheehan
Received: 22 July 2016 / Revised: 5 November 2016 / Accepted: 8 November 2016 / Published: 28 November 2016
(This article belongs to the Collection Advances in Proteomic Research)
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Abstract

The myogenic regulatory factors (MRFs) and myocyte enhancer factor 2 (MEF2) transcription factors have been extensively studied as key transcription factors that regulate myogenic gene expression. However, few reports on the molecular mechanism that modulates chromatin remodeling during skeletal muscle differentiation are available. We reported here that the expression of the H3-K9 methyltransferase Suv39h1 was decreased during myoblast differentiation. Ectopic expression of Suv39h1 could inhibit myoblast differentiation, increasing H3-K9 methylation levels, whereas knockdown of Suv39h1 stimulated myoblast differentiation. Furthermore, Suv39h1 interacted with MEF2C directly and inhibited MEF2 transcription activity in a dose-dependent manner. Together, our studies revealed a molecular mechanism wherein Suv39h1 modulated myogenic gene expression and activation during skeletal muscle differentiation. View Full-Text
Keywords: epigenetic modification; histone methylation; Suv39h1; protein interaction; MEF2; myoblasts differentiation epigenetic modification; histone methylation; Suv39h1; protein interaction; MEF2; myoblasts differentiation
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Jin, W.; Shang, Y.; Peng, J.; Jiang, S. Histone H3 Methyltransferase Suv39h1 Prevents Myogenic Terminal Differentiation by Repressing MEF2 Activity in Muscle Cells. Int. J. Mol. Sci. 2016, 17, 1908.

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