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Int. J. Mol. Sci. 2016, 17(11), 1945; doi:10.3390/ijms17111945

Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass

1
Clinic for Paediatric Cardiology Heart Centre, University of Leipzig, 04289 Leipzig, Germany
2
Rudolf-Boehm-Institute for Pharmacology and Toxicology, University of Leipzig, 04107 Leipzig, Germany
3
Department of Cardiology, Angiology and Internal Intensive Care Medicine, St. Georg Hospital, Academic Medical Centre, University of Leipzig, 04129 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 21 July 2016 / Revised: 2 November 2016 / Accepted: 15 November 2016 / Published: 21 November 2016
(This article belongs to the Special Issue Neuroprotective Strategies 2016)
View Full-Text   |   Download PDF [374 KB, uploaded 21 November 2016]   |  

Abstract

Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain. View Full-Text
Keywords: cardiopulmonary bypass; neuroprotection; heart-lung machine cardiopulmonary bypass; neuroprotection; heart-lung machine
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Salameh, A.; Dhein, S.; Dähnert, I.; Klein, N. Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass. Int. J. Mol. Sci. 2016, 17, 1945.

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