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Int. J. Mol. Sci. 2016, 17(11), 1935; doi:10.3390/ijms17111935

Clinical Decision-Making in the Treatment of Schizophrenia: Focus on Long-Acting Injectable Antipsychotics

1
Centre Hospitalier et Universitaire, Department of Psychiatry, University of Auvergne, EA 7280, 63000 Clermont-Ferrand, France
2
French Society for Biological Psychiatry and Neuropsychopharmacology, CH Sainte Anne, 75674 Paris, France
3
Fondation FondaMental, Hôpital Albert Chenevier, Depatment of Psychiatry, 94000 Créteil, France
4
Centre Hospitalier et Universitaire, Department of Public Health, University of Auvergne, EA 4681 PEPRADE, 63000 Clermont-Ferrand, France
*
Author to whom correspondence should be addressed.
Academic Editor: Domenico De Berardis
Received: 20 September 2016 / Revised: 9 November 2016 / Accepted: 14 November 2016 / Published: 19 November 2016
(This article belongs to the Special Issue Antipsychotics)
View Full-Text   |   Download PDF [354 KB, uploaded 19 November 2016]   |  

Abstract

The purpose of this study was to identify clinician characteristics associated with higher prescription rates of long-acting injectable (LAI) antipsychotics, as well as the sources that influence medical decision-making regarding the treatment of schizophrenia. We surveyed 202 psychiatrists during six regional French conferences (Bordeaux, Lyon, Marseille, Nice, Paris, and Strasbourg). Data on the characteristics of practice, prescription rates of antipsychotic, and information sources about their clinical decisions were collected. Most psychiatrists used second-generation antipsychotics (SGAs), and preferentially an oral formulation, in the treatment of schizophrenia. LAI SGAs were prescribed to 30.4% of schizophrenic patients. The duration and type of practice did not influence the class or formulation of antipsychotics used. The clinicians following the higher percentage of schizophrenic patients were associated with a higher use of LAI antipsychotics and a lower use of oral SGAs. Personal experience, government regulatory approval, and guidelines for the treatment of schizophrenia were the three main contributing factors guiding clinicians’ decision-making regarding the treatment of schizophrenia. The more clinicians follow schizophrenic patients, the more they use LAI antipsychotics. The development of specialized programs with top specialists should lead to better use of LAI antipsychotics in the treatment of schizophrenia. View Full-Text
Keywords: long-acting injectable; antipsychotic; decision-making; guidelines; schizophrenia long-acting injectable; antipsychotic; decision-making; guidelines; schizophrenia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Samalin, L.; Garnier, M.; Auclair, C.; Llorca, P.-M. Clinical Decision-Making in the Treatment of Schizophrenia: Focus on Long-Acting Injectable Antipsychotics. Int. J. Mol. Sci. 2016, 17, 1935.

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