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Int. J. Mol. Sci. 2016, 17(11), 1851; doi:10.3390/ijms17111851

Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice

1
Biocenter Oulu, University of Oulu, FI-90220 Oulu, Finland
2
Faculty of Medicine, Department of Internal Medicine, University of Oulu, FI-90220 Oulu, Finland
3
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, FI-90220 Oulu, Finland
4
Department of Experimental and Clinical Medicine, Marche Polytechnic University, IT-60126 Ancona, Italy
5
Center for Life-Course Health Research, University of Oulu, FI-90220 Oulu, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Marica Bakovic
Received: 30 August 2016 / Revised: 1 November 2016 / Accepted: 2 November 2016 / Published: 7 November 2016
(This article belongs to the Special Issue Nutrigenomics of Risk Factors for Disease)
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Abstract

Genetic variants in the fat mass- and obesity-associated gene Fto are linked to the onset of obesity in humans. The causal role of the FTO protein in obesity is supported by evidence obtained from transgenic mice; however, the underlying molecular pathways pertaining to the role of FTO in obesity have yet to be established. In this study, we investigate the Fto gene in mouse brown adipose tissue and in the browning process of white adipose tissue. We analyze distinct structural and molecular factors in brown and white fat depots of Fto-deficient mice under normal and obesogenic conditions. We report significant alterations in the morphology of adipose tissue depots and the expression of mRNA and microRNA related to brown adipogenesis and metabolism in Fto-deficient mice. Furthermore, we show that high-fat feeding does not attenuate the browning process of Fto-deficient white adipose tissue as observed in wild-type tissue, suggesting a triggering effect of the FTO pathways by the dietary environment. View Full-Text
Keywords: FTO; brown adipose tissue (BAT); white adipose tissue (WAT) browning; gene expression; microRNA expression; high-fat diet FTO; brown adipose tissue (BAT); white adipose tissue (WAT) browning; gene expression; microRNA expression; high-fat diet
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ronkainen, J.; Mondini, E.; Cinti, F.; Cinti, S.; Sebért, S.; Savolainen, M.J.; Salonurmi, T. Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice. Int. J. Mol. Sci. 2016, 17, 1851.

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