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Int. J. Mol. Sci. 2016, 17(10), 1700;

Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome 00189, Italy
International Consortium for Mood and Psychotic Disorders Research, Mailman Research Center, McLean Hospital, Belmont, MA 02468, USA
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa 16126, Italy
Department of Psychiatry, University of Naples SUN, Naples I-80138, Italy
Author to whom correspondence should be addressed.
Academic Editors: Domenico De Berardis and Michele Fornaro
Received: 21 July 2016 / Revised: 19 September 2016 / Accepted: 22 September 2016 / Published: 11 October 2016
(This article belongs to the Special Issue Antipsychotics)
View Full-Text   |   Download PDF [236 KB, uploaded 11 October 2016]


Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior. View Full-Text
Keywords: antipsychotic; aripiprazole; asenapine; atypical; clozapine; olanzapine; quetiapine; risperidone; second-generation; suicide; ziprasidone antipsychotic; aripiprazole; asenapine; atypical; clozapine; olanzapine; quetiapine; risperidone; second-generation; suicide; ziprasidone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pompili, M.; Baldessarini, R.J.; Forte, A.; Erbuto, D.; Serafini, G.; Fiorillo, A.; Amore, M.; Girardi, P. Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview. Int. J. Mol. Sci. 2016, 17, 1700.

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