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Int. J. Mol. Sci. 2016, 17(10), 1660; doi:10.3390/ijms17101660

Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice

College of Pharmacy, Sahmyook University, Seoul 01795, Korea
College of Pharmacy, Chungbuk National University, Cheongju 28644, Korea
Wellness R&D Center, Univera, Inc., Seoul 04782, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 22 August 2016 / Revised: 24 September 2016 / Accepted: 27 September 2016 / Published: 30 September 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
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Chronic stress generally experienced in our daily lives; is known to augment disease vulnerability by suppressing the host immune system. In the present study; the effect of modified Aloe polysaccharide (MAP) on chronic stress-induced immunosuppression was studied; this Aloe compound was characterized in our earlier study. Mice were orally administered with MAP for 24 days and exposed to electric foot shock (EFS; duration; 3 min; interval; 10 s; intensity; 2 mA) for 17 days. The stress-related immunosuppression and restorative effect of MAP were then analyzed by measuring various immunological parameters. MAP treatment alleviated lymphoid atrophy and body weight loss. The numbers of lymphocyte subsets were significantly normalized in MAP-treated mice. Oral administration of MAP also restored the proliferative activities of lymphocytes; ovalbumin (OVA)-specific T cell proliferation; antibody production; and the cell killing activity of cytotoxic T lymphocytes. In summary; oral administration of MAP ameliorated chronic EFS stress-induced immunosuppression. View Full-Text
Keywords: modified Aloe polysaccharide (MAP); electric foot shock (EFS); chronic stress; immune restoration; in vivo cytotoxic T lymphocyte (CTL) modified Aloe polysaccharide (MAP); electric foot shock (EFS); chronic stress; immune restoration; in vivo cytotoxic T lymphocyte (CTL)

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, Y.; Im, S.-A.; Kim, J.; Lee, S.; Kwon, J.; Lee, H.; Kong, H.; Song, Y.; Shin, E.; Do, S.-G.; Lee, C.-K.; Kim, K. Modified Aloe Polysaccharide Restores Chronic Stress-Induced Immunosuppression in Mice. Int. J. Mol. Sci. 2016, 17, 1660.

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