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Int. J. Mol. Sci. 2016, 17(10), 1624; doi:10.3390/ijms17101624

Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids

1
INRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, France
2
Lee Kong Chian School of Medicine, Nanyang Technological University, 637553 Singapore, Singapore
3
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Béatrice Desvergne
Received: 26 July 2016 / Revised: 5 September 2016 / Accepted: 15 September 2016 / Published: 24 September 2016
View Full-Text   |   Download PDF [4529 KB, uploaded 24 September 2016]   |  

Abstract

The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα−/− male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand. View Full-Text
Keywords: nuclear receptors; PPARα; dietary fatty acids; fasting; steatosis; polyunsaturated fatty acids nuclear receptors; PPARα; dietary fatty acids; fasting; steatosis; polyunsaturated fatty acids
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Polizzi, A.; Fouché, E.; Ducheix, S.; Lasserre, F.; Marmugi, A.P.; Mselli-Lakhal, L.; Loiseau, N.; Wahli, W.; Guillou, H.; Montagner, A. Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids. Int. J. Mol. Sci. 2016, 17, 1624.

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