Next Article in Journal
Computational Analysis of Structure-Based Interactions for Novel H1-Antihistamines
Next Article in Special Issue
Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease
Previous Article in Journal
The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives
Previous Article in Special Issue
Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(1), 128; doi:10.3390/ijms17010128

Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches

1
Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK
2
Department of Respiratory Medicine, University Hospitals of North Midlands, Stoke-on-Trent ST4 6QG, UK
3
Guy Hilton Research Centre, Institute of Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 7 December 2015 / Revised: 7 January 2016 / Accepted: 11 January 2016 / Published: 19 January 2016
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
View Full-Text   |   Download PDF [1296 KB, uploaded 19 January 2016]   |  

Abstract

The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC) show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases. View Full-Text
Keywords: lung development; lung regeneration; lung stem cells; stem cell-mediated therapeutics; signalling pathways in lung repair; lung tissue engineering lung development; lung regeneration; lung stem cells; stem cell-mediated therapeutics; signalling pathways in lung repair; lung tissue engineering
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Akram, K.M.; Patel, N.; Spiteri, M.A.; Forsyth, N.R. Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches. Int. J. Mol. Sci. 2016, 17, 128.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top