In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin
AbstractHerbal compounds that have notable therapeutic effect upon Alzheimer's disease (AD) have frequently been found, despite the recent failure of late-stage clinical drugs. Icariin, which is isolated from Epimedium brevicornum, is widely reported to exhibit significant anti-AD effects in in vitro and in vivo studies. However, the molecular mechanism remains thus far unclear. In this work, the anti-AD mechanisms of icariin were investigated at a target network level assisted by an in silico target identification program (INVDOCK). The results suggested that the anti-AD effects of icariin may be contributed by: attenuation of hyperphosphorylation of tau protein, anti-inflammation and regulation of Ca2+ homeostasis. Our results may provide assistance in understanding the molecular mechanism and further developing icariin into promising anti-AD agents. View Full-Text
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Cui, Z.; Sheng, Z.; Yan, X.; Cao, Z.; Tang, K. In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin. Int. J. Mol. Sci. 2016, 17, 113.
Cui Z, Sheng Z, Yan X, Cao Z, Tang K. In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin. International Journal of Molecular Sciences. 2016; 17(1):113.Chicago/Turabian Style
Cui, Zhijie; Sheng, Zhen; Yan, Xinmiao; Cao, Zhiwei; Tang, Kailin. 2016. "In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin." Int. J. Mol. Sci. 17, no. 1: 113.
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