Next Article in Journal
Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions
Previous Article in Journal
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(1), 113; doi:10.3390/ijms17010113

In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin

1
School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China
2
Advanced Institute of Translational Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jesus De Julián Ortiz
Received: 1 December 2015 / Revised: 4 January 2016 / Accepted: 11 January 2016 / Published: 15 January 2016
(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
View Full-Text   |   Download PDF [1286 KB, uploaded 15 January 2016]   |  

Abstract

Herbal compounds that have notable therapeutic effect upon Alzheimer's disease (AD) have frequently been found, despite the recent failure of late-stage clinical drugs. Icariin, which is isolated from Epimedium brevicornum, is widely reported to exhibit significant anti-AD effects in in vitro and in vivo studies. However, the molecular mechanism remains thus far unclear. In this work, the anti-AD mechanisms of icariin were investigated at a target network level assisted by an in silico target identification program (INVDOCK). The results suggested that the anti-AD effects of icariin may be contributed by: attenuation of hyperphosphorylation of tau protein, anti-inflammation and regulation of Ca2+ homeostasis. Our results may provide assistance in understanding the molecular mechanism and further developing icariin into promising anti-AD agents. View Full-Text
Keywords: icariin; Alzheimer’s disease (AD); INVDOCK; network pharmacology icariin; Alzheimer’s disease (AD); INVDOCK; network pharmacology
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cui, Z.; Sheng, Z.; Yan, X.; Cao, Z.; Tang, K. In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin. Int. J. Mol. Sci. 2016, 17, 113.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top