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Int. J. Mol. Sci. 2016, 17(1), 110; doi:10.3390/ijms17010110

Retinal Cell Degeneration in Animal Models

1
Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu 501-1194, Japan
2
Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
3
Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu 501-1194, Japan
4
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
5
Department of Oral and Maxillofacial Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 23 October 2015 / Revised: 25 December 2015 / Accepted: 8 January 2016 / Published: 15 January 2016
(This article belongs to the Special Issue Neuroprotective Strategies 2015)
View Full-Text   |   Download PDF [1207 KB, uploaded 15 January 2016]   |  

Abstract

The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl2-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage. View Full-Text
Keywords: retinal cell degeneration; NMDA; CoCl2; EAE; ischemia; nerve crush; light-induced; animal model retinal cell degeneration; NMDA; CoCl2; EAE; ischemia; nerve crush; light-induced; animal model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Niwa, M.; Aoki, H.; Hirata, A.; Tomita, H.; Green, P.G.; Hara, A. Retinal Cell Degeneration in Animal Models. Int. J. Mol. Sci. 2016, 17, 110.

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