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Int. J. Mol. Sci. 2015, 16(8), 19537-19552; doi:10.3390/ijms160819537

Therapeutic Strategies and New Intervention Points in Chronic Hepatitis Delta Virus Infection

1
Huron Peak Ave., Superior, CO 80027, USA
2
Allevagen, LLC, 4105 Perry St., Denver, CO 80212, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Tatsuo Kanda
Received: 1 June 2015 / Revised: 5 August 2015 / Accepted: 7 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Viral Hepatitis Research)
View Full-Text   |   Download PDF [1061 KB, uploaded 18 August 2015]   |  

Abstract

Chronic hepatitis delta virus infection (CHD) is a condition arising from super-infection of hepatitis B virus (HBV)-infected patients, resulting in a more rapid advance in liver pathology and hepatocellular carcinoma than is observed for HBV mono-infection. Although hepatitis delta virus (HDV) is structurally simple, its life cycle involves the complex participation of host enzymes, HBV-derived surface antigen (HBsAg), and HDV-auto-ribozyme and hepatitis delta antigen (HDAg) activities. Unsatisfactory clinical trial results with interferon-based therapies are motivating researchers to adjust and redirect the approach to CHD drug development. This new effort will likely require additional structural and functional studies of the viral and cellular/host components involved in the HDV replication cycle. This review highlights recent work aimed at new drug interventions for CHD, with interpretation of key pre-clinical- and clinical trial outcomes and a discussion of promising new technological approaches to antiviral drug design. View Full-Text
Keywords: HDV; HBV; HIV; deltavirus; hepatitis; therapeutic; clinical; trial HDV; HBV; HIV; deltavirus; hepatitis; therapeutic; clinical; trial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, Z.; King, T. Therapeutic Strategies and New Intervention Points in Chronic Hepatitis Delta Virus Infection. Int. J. Mol. Sci. 2015, 16, 19537-19552.

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