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Int. J. Mol. Sci. 2015, 16(8), 18018-18032; doi:10.3390/ijms160818018

Stromal Cell-Derived Factor-1α Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats

Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Ehime 791-0295, Japan
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Chris Sobey
Received: 8 May 2015 / Revised: 8 July 2015 / Accepted: 23 July 2015 / Published: 5 August 2015
(This article belongs to the Special Issue The Immune System and Inflammation in Cerebral Ischemia)
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Abstract

Owing to progress in perinatal medicine, the survival of preterm newborns has markedly increased. However, the incidence of cerebral palsy has risen in association with increased preterm birth. Cerebral palsy is largely caused by cerebral hypoxic ischemia (HI), for which there are no effective medical treatments. We evaluated the effects of stromal cell-derived factor-1α (SDF-1α) on neonatal brain damage in rats. Left common carotid (LCC) arteries of seven-day-old Wistar rat pups were ligated, and animals were exposed to hypoxic gas to cause cerebral HI. Behavioral tests revealed that the memory and spatial perception abilities were disturbed in HI animals, and that SDF-1α treatment improved these cognitive functions. Motor coordination was also impaired after HI but was unimproved by SDF-1α treatment. SDF-1α reduced intracranial inflammation and induced cerebral remyelination, as indicated by the immunohistochemistry results. These data suggest that SDF-1α specifically influences spatial perception abilities in neonatal HI encephalopathy. View Full-Text
Keywords: hypoxic-ischemic encephalopathy; magnetic resonance imaging; morris water maze test; rat; Rotarod test; stromal cell-derived factor-1α; TTC staining hypoxic-ischemic encephalopathy; magnetic resonance imaging; morris water maze test; rat; Rotarod test; stromal cell-derived factor-1α; TTC staining
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mori, M.; Matsubara, K.; Matsubara, Y.; Uchikura, Y.; Hashimoto, H.; Fujioka, T.; Matsumoto, T. Stromal Cell-Derived Factor-1α Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats. Int. J. Mol. Sci. 2015, 16, 18018-18032.

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