Hepatitis B Virus Infection, MicroRNAs and Liver Disease
AbstractHepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently,microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV. View Full-Text
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Sarkar, N.; Chakravarty, R. Hepatitis B Virus Infection, MicroRNAs and Liver Disease. Int. J. Mol. Sci. 2015, 16, 17746-17762.
Sarkar N, Chakravarty R. Hepatitis B Virus Infection, MicroRNAs and Liver Disease. International Journal of Molecular Sciences. 2015; 16(8):17746-17762.Chicago/Turabian Style
Sarkar, Neelakshi; Chakravarty, Runu. 2015. "Hepatitis B Virus Infection, MicroRNAs and Liver Disease." Int. J. Mol. Sci. 16, no. 8: 17746-17762.