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Int. J. Mol. Sci. 2015, 16(8), 17746-17762; doi:10.3390/ijms160817746

Hepatitis B Virus Infection, MicroRNAs and Liver Disease

ICMR Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata-700010, India
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Author to whom correspondence should be addressed.
Academic Editor: Tatsuo Kanda
Received: 25 June 2015 / Revised: 21 July 2015 / Accepted: 22 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Viral Hepatitis Research)
View Full-Text   |   Download PDF [1108 KB, uploaded 3 August 2015]   |  

Abstract

Hepatitis B virus (HBV) attacks the liver and can cause both acute as well as chronic liver diseases which might lead to liver cirrhosis and hepatocellular carcinoma. Regardless of the availability of a vaccine and numerous treatment options, HBV is a major cause of morbidity and mortality across the world. Recently,microRNAs (miRNAs) have emerged as important modulators of gene function. Studies on the role of miRNA in the regulation of hepatitis B virus gene expression have been the focus of modern antiviral research. miRNAs can regulate viral replication and pathogenesis in a number of different ways, which includefacilitation, direct or indirect inhibition, activation of immune response, epigenetic modulation, etc. Nevertheless, these mechanisms can appropriately be used with a diagnosticand/or therapeutic approach. The present review is an attempt to classify specific miRNAs that are reported to be associated with various aspects of hepatitis B biology, in order to precisely present the participation of individual miRNAs in multiple aspects relating to HBV. View Full-Text
Keywords: HBV; miRNA; chronic; liver cirrhosis; hepatocellular carcinoma HBV; miRNA; chronic; liver cirrhosis; hepatocellular carcinoma
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Sarkar, N.; Chakravarty, R. Hepatitis B Virus Infection, MicroRNAs and Liver Disease. Int. J. Mol. Sci. 2015, 16, 17746-17762.

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