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Int. J. Mol. Sci. 2015, 16(8), 17668-17681; doi:10.3390/ijms160817668

Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives

College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China
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Author to whom correspondence should be addressed.
Academic Editor: Iolanda Francolini
Received: 18 June 2015 / Revised: 17 July 2015 / Accepted: 24 July 2015 / Published: 31 July 2015
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [1989 KB, uploaded 31 July 2015]   |  

Abstract

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents. View Full-Text
Keywords: tanshinone; pyrrolidine; antibacterial; reactive oxygen species (ROS); membrane tanshinone; pyrrolidine; antibacterial; reactive oxygen species (ROS); membrane
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, D.; Zhang, W.; Wang, T.; Li, N.; Mu, H.; Zhang, J.; Duan, J. Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives. Int. J. Mol. Sci. 2015, 16, 17668-17681.

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