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Int. J. Mol. Sci. 2015, 16(8), 16953-16965; doi:10.3390/ijms160816953

MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers

1
INSERM, U1183, Institute of Regenerative Medicine and Biotherapy, University Hospital Saint Eloi, Montpellier 34295, France
2
University of Montpellier, Montpellier 34090, France
3
Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes, Santiago 7620001, Chile
4
Cells for Cells, Santiago 7620001, Chile
5
Exploratory Unit, Sanofi R & D, Montpellier 34184, France
6
Hospital Félix Bulnes, Santiago 7510021, Chile
7
Hospital Barros Luco, Santiago 8900085, Chile
8
Clinical Department for Osteoarticular Diseases, University Hospital Lapeyronie, Montpellier 34295, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Gloria Ravegnini and Sabrina Angelini
Received: 29 May 2015 / Revised: 10 July 2015 / Accepted: 15 July 2015 / Published: 27 July 2015
(This article belongs to the Special Issue Pharmacogenetics and Personalized Medicine)
View Full-Text   |   Download PDF [1946 KB, uploaded 27 July 2015]   |  

Abstract

MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. View Full-Text
Keywords: lupus; lupus nephritis; naive B cells; memory B cells; microRNAs lupus; lupus nephritis; naive B cells; memory B cells; microRNAs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Duroux-Richard, I.; Cuenca, J.; Ponsolles, C.; Badilla Piñeiro, A.; Gonzalez, F.; Roubert, C.; Areny, R.; Chea, R.; Pefaur, J.; Pers, Y.-M.; Figueroa, F.E.; Jorgensen, C.; Khoury, M.; Apparailly, F. MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. Int. J. Mol. Sci. 2015, 16, 16953-16965.

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