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Int. J. Mol. Sci. 2015, 16(7), 16125-16143; doi:10.3390/ijms160716125

Sex-Specific Patterns of Aberrant Brain Function in First-Episode Treatment-Naive Patients with Schizophrenia

1
The Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2
Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Branch Hospital of West China Hospital, Sichuan University, Chengdu 610041, China
3
Biobank, West China Hospital, Sichuan University, Chengdu 610041, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 28 April 2015 / Revised: 3 June 2015 / Accepted: 26 June 2015 / Published: 16 July 2015
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Abstract

Male and female patients with schizophrenia show significant differences in a number of important clinical features, yet the neural substrates of these differences are still poorly understood. Here we explored the sex differences in the brain functional aberrations in 124 treatment-naïve patients with first-episode schizophrenia (61 males), compared with 102 age-matched healthy controls (50 males). Maps of degree centrality (DC) and amplitude of low-frequency fluctuations (ALFF) were constructed using resting-state functional magnetic resonance imaging data and compared between groups. We found that: (1) Selective DC reduction was observed in the right putamen (Put_R) in male patients and the left middle frontal gyrus (MFG) in female patients; (2) Functional connectivity analysis (using Put_R and MFG as seeds) found that male and female patients have disturbed functional integration in two separate networks, i.e., the sensorimotor network and the default mode network; (3) Significant ALFF alterations were also observed in these two networks in both genders; (4) Sex specific brain functional alterations were associated with various symptoms in patients. These results suggested that sex-specific patterns of functional aberration existed in schizophrenia, and these patterns were associated with the clinical features both in male and female patients. View Full-Text
Keywords: schizophrenia; functional MRI; sex difference; brain functional network schizophrenia; functional MRI; sex difference; brain functional network
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Lei, W.; Li, M.; Deng, W.; Zhou, Y.; Ma, X.; Wang, Q.; Guo, W.; Li, Y.; Jiang, L.; Han, Y.; Huang, C.; Hu, X.; Li, T. Sex-Specific Patterns of Aberrant Brain Function in First-Episode Treatment-Naive Patients with Schizophrenia. Int. J. Mol. Sci. 2015, 16, 16125-16143.

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