Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration
AbstractAnorganic bovine bone matrix (Bio-Oss®) has been used for a long time for bone graft regeneration, but has poor osteoinductive capability. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been suggested to overcome this limitation of Bio-Oss®. In the present study, heparin-mediated rhBMP-2 was combined with Bio-Oss® in animal experiments to investigate bone formation performance; heparin was used to control rhBMP-2 release. Two calvarial defects (8 mm diameter) were formed in a white rabbit model and then implanted or not (controls) with Bio-Oss® or BMP-2/Bio-Oss®. The Bio-Oss® and BMP-2/Bio-Oss® groups had significantly greater new bone areas (expressed as percentages of augmented areas) than the non-implanted controls at four and eight weeks after surgery, and the BMP-2/Bio-Oss® group (16.50 ± 2.87 (n = 6)) had significantly greater new bone areas than the Bio-Oss® group (9.43 ± 3.73 (n = 6)) at four weeks. These findings suggest that rhBMP-2 treated heparinized Bio-Oss® markedly enhances bone regeneration. View Full-Text
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Huh, J.-B.; Yang, J.-J.; Choi, K.-H.; Bae, J.H.; Lee, J.-Y.; Kim, S.-E.; Shin, S.-W. Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration. Int. J. Mol. Sci. 2015, 16, 16034-16052.
Huh J-B, Yang J-J, Choi K-H, Bae JH, Lee J-Y, Kim S-E, Shin S-W. Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration. International Journal of Molecular Sciences. 2015; 16(7):16034-16052.Chicago/Turabian Style
Huh, Jung-Bo; Yang, June-Jip; Choi, Kyung-Hee; Bae, Ji H.; Lee, Jeong-Yeol; Kim, Sung-Eun; Shin, Sang-Wan. 2015. "Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration." Int. J. Mol. Sci. 16, no. 7: 16034-16052.