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Int. J. Mol. Sci. 2015, 16(7), 16034-16052; doi:10.3390/ijms160716034

Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration

1
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, YangSan 676-870, Korea
2
Advanced Prosthodontics, Postgraduate School of Clinical Dentistry, Institute for Clinical Dental Research, Korea University, Seoul 152-703, Korea
3
Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Korea
4
Department of Orthopedic Surgery & Rare Diseases Institute, Korea University Medical Center, Guro Hospital, Seoul 152-703, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 22 April 2015 / Revised: 24 June 2015 / Accepted: 7 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
View Full-Text   |   Download PDF [12495 KB, uploaded 14 July 2015]   |  

Abstract

Anorganic bovine bone matrix (Bio-Oss®) has been used for a long time for bone graft regeneration, but has poor osteoinductive capability. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been suggested to overcome this limitation of Bio-Oss®. In the present study, heparin-mediated rhBMP-2 was combined with Bio-Oss® in animal experiments to investigate bone formation performance; heparin was used to control rhBMP-2 release. Two calvarial defects (8 mm diameter) were formed in a white rabbit model and then implanted or not (controls) with Bio-Oss® or BMP-2/Bio-Oss®. The Bio-Oss® and BMP-2/Bio-Oss® groups had significantly greater new bone areas (expressed as percentages of augmented areas) than the non-implanted controls at four and eight weeks after surgery, and the BMP-2/Bio-Oss® group (16.50 ± 2.87 (n = 6)) had significantly greater new bone areas than the Bio-Oss® group (9.43 ± 3.73 (n = 6)) at four weeks. These findings suggest that rhBMP-2 treated heparinized Bio-Oss® markedly enhances bone regeneration. View Full-Text
Keywords: bone regeneration; anorganic bovine bone; Bio-Oss®; rhBMP-2 bone regeneration; anorganic bovine bone; Bio-Oss®; rhBMP-2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huh, J.-B.; Yang, J.-J.; Choi, K.-H.; Bae, J.H.; Lee, J.-Y.; Kim, S.-E.; Shin, S.-W. Effect of rhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration. Int. J. Mol. Sci. 2015, 16, 16034-16052.

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