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Int. J. Mol. Sci. 2015, 16(7), 15800-15810; doi:10.3390/ijms160715800

Does Short-Term Dietary Omega-3 Fatty Acid Supplementation Influence Brain Hippocampus Gene Expression of Zinc Transporter-3?

Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Cenk Suphioglu
Received: 15 January 2015 / Revised: 19 June 2015 / Accepted: 6 July 2015 / Published: 13 July 2015
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Diseases)
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Dietary omega-3 fatty acids have been recognized to improve brain cognitive function. Deficiency leads to dysfunctional zinc metabolism associated with learning and memory impairment. The objective of this study is to explore the effect of short-term dietary omega-3 fatty acids on hippocampus gene expression at the molecular level in relation to spatial recognition memory in mice. A total of 24 male BALB/c mice were randomly divided into four groups and fed a standard pellet as a control group (CTL, n = 6), standard pellet added with 10% (w/w) fish oil (FO, n = 6), 10% (w/w) soybean oil (SO, n = 6) and 10% (w/w) butter (BT, n = 6). After 3 weeks on the treatment diets, spatial-recognition memory was tested on a Y-maze. The hippocampus gene expression was determined using a real-time PCR. The results showed that 3 weeks of dietary omega-3 fatty acid supplementation improved cognitive performance along with the up-regulation of α-synuclein, calmodulin and transthyretin genes expression. In addition, dietary omega-3 fatty acid deficiency increased the level of ZnT3 gene and subsequently reduced cognitive performance in mice. These results indicate that the increased the ZnT3 levels caused by the deficiency of omega-3 fatty acids produced an abnormal zinc metabolism that in turn impaired the brain cognitive performance in mice. View Full-Text
Keywords: omega-3 fatty acid; brain gene expression; ZnT3; cognitive function omega-3 fatty acid; brain gene expression; ZnT3; cognitive function

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sopian, N.F.A.; Ajat, M.; Shafie, N.I.; Noor, M.H.M.; Ebrahimi, M.; Rajion, M.A.; Meng, G.Y.; Ahmad, H. Does Short-Term Dietary Omega-3 Fatty Acid Supplementation Influence Brain Hippocampus Gene Expression of Zinc Transporter-3? Int. J. Mol. Sci. 2015, 16, 15800-15810.

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