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Int. J. Mol. Sci. 2015, 16(5), 9420-9430; doi:10.3390/ijms16059420

Induction of Nickel Accumulation in Response to Zinc Deficiency in Arabidopsis thaliana

1
Graduate School of Bioresources, Mie University, Kurimamachiya-cho 1577, Tsu, Mie 514-8507, Japan
2
Faculty of Bioresources, Mie University, Kurimamachiya-cho 1577, Tsu, Mie 514-8507, Japan
Present address: Graduate School of Biosphere Science, Hiroshima University, Kagamiyama 1-7-1, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
*
Author to whom correspondence should be addressed.
Academic Editor: Hatem Rouached
Received: 27 February 2015 / Revised: 17 April 2015 / Accepted: 20 April 2015 / Published: 27 April 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Excessive accumulation of nickel (Ni) can be toxic to plants. In Arabidopsis thaliana, the Fe2+ transporter, iron (Fe)-regulated transporter1 (IRT1), mediates Fe uptake and also implicates in Ni2+ uptake at roots; however, the underlying mechanism of Ni2+ uptake and accumulation remains unelucidated. In the present study, we found that zinc (Zn) deficient conditions resulted in increased accumulation of Ni in plants, particularly in roots, in A. thaliana. In order to elucidate the underlying mechanisms of Ni uptake correlating zinc condition, we traced 63Ni isotope in response to Zn and found that (i) Zn deficiency induces short-term Ni2+ absorption and (ii) Zn2+ inhibits Ni2+ uptake, suggesting competitive uptake between Ni and Zn. Furthermore, the Zrt/Irt-like protein 3 (ZIP3)-defective mutant with an elevated Zn-deficient response exhibited higher Ni accumulation than the wild type, further supporting that the response to Zn deficiency induces Ni accumulation. Previously, expression profile study demonstrated that IRT1 expression is not inducible by Zn deficiency. In the present study, we found increased Ni accumulation in IRT1-null mutant under Zn deficiency in agar culture. These suggest that Zn deficiency induces Ni accumulation in an IRT1-independen manner. The present study revealed that Ni accumulation is inducible in response to Zn deficiency, which may be attributable to a Zn uptake transporter induced by Zn deficiency. View Full-Text
Keywords: Arabidopsis thaliana; nickel; transporter; zinc Arabidopsis thaliana; nickel; transporter; zinc
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nishida, S.; Kato, A.; Tsuzuki, C.; Yoshida, J.; Mizuno, T. Induction of Nickel Accumulation in Response to Zinc Deficiency in Arabidopsis thaliana. Int. J. Mol. Sci. 2015, 16, 9420-9430.

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