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Int. J. Mol. Sci. 2015, 16(5), 11055-11086; doi:10.3390/ijms160511055

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

1,2,†
,
1,2,†
and
1,2,3,4,*
1
Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
2
Department of Oncology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
3
Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
4
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 13 March 2015 / Revised: 30 April 2015 / Accepted: 8 May 2015 / Published: 15 May 2015
(This article belongs to the Collection Advances in Molecular Oncology)
View Full-Text   |   Download PDF [996 KB, uploaded 15 May 2015]   |  

Abstract

Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemoprevention. View Full-Text
Keywords: tumor microenvironment; cancer cell metabolism; hypoxia; acidosis; cancer therapy tumor microenvironment; cancer cell metabolism; hypoxia; acidosis; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Justus, C.R.; Sanderlin, E.J.; Yang, L.V. Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment. Int. J. Mol. Sci. 2015, 16, 11055-11086.

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