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Int. J. Mol. Sci. 2015, 16(3), 5528-5554; doi:10.3390/ijms16035528

Mechanisms by Which Different Functional States of Mitochondria Define Yeast Longevity

Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 2 February 2015 / Revised: 5 March 2015 / Accepted: 5 March 2015 / Published: 11 March 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Mitochondrial functionality is vital to organismal physiology. A body of evidence supports the notion that an age-related progressive decline in mitochondrial function is a hallmark of cellular and organismal aging in evolutionarily distant eukaryotes. Studies of the baker’s yeast Saccharomyces cerevisiae, a unicellular eukaryote, have led to discoveries of genes, signaling pathways and chemical compounds that modulate longevity-defining cellular processes in eukaryotic organisms across phyla. These studies have provided deep insights into mechanistic links that exist between different traits of mitochondrial functionality and cellular aging. The molecular mechanisms underlying the essential role of mitochondria as signaling organelles in yeast aging have begun to emerge. In this review, we discuss recent progress in understanding mechanisms by which different functional states of mitochondria define yeast longevity, outline the most important unanswered questions and suggest directions for future research. View Full-Text
Keywords: yeast; cellular aging; longevity regulation; metabolism; interorganellar communications; mitochondria; mitochondrial respiration; mitochondrial membrane potential; mitochondrial reactive oxygen species; mitochondrial lipidome yeast; cellular aging; longevity regulation; metabolism; interorganellar communications; mitochondria; mitochondrial respiration; mitochondrial membrane potential; mitochondrial reactive oxygen species; mitochondrial lipidome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Beach, A.; Leonov, A.; Arlia-Ciommo, A.; Svistkova, V.; Lutchman, V.; Titorenko, V.I. Mechanisms by Which Different Functional States of Mitochondria Define Yeast Longevity. Int. J. Mol. Sci. 2015, 16, 5528-5554.

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