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Int. J. Mol. Sci. 2015, 16(3), 4416-4428; doi:10.3390/ijms16034416

Pharmacogenetics Informed Decision Making in Adolescent Psychiatric Treatment: A Clinical Case Report

Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
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Author to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 19 December 2014 / Revised: 11 February 2015 / Accepted: 12 February 2015 / Published: 20 February 2015
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Abstract

Advances made in genetic testing and tools applied to pharmacogenetics are increasingly being used to inform clinicians in fields such as oncology, hematology, diabetes (endocrinology), cardiology and expanding into psychiatry by examining the influences of genetics on drug efficacy and metabolism. We present a clinical case example of an adolescent male with anxiety, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder who did not tolerate numerous medications and dosages over several years in attempts to manage his symptoms. Pharmacogenetics testing was performed and DNA results on this individual elucidated the potential pitfalls in medication use because of specific pharmacodynamic and pharmacokinetic differences specifically involving polymorphisms of genes in the cytochrome p450 enzyme system. Future studies and reports are needed to further illustrate and determine the type of individualized medicine approach required to treat individuals based on their specific gene patterns. Growing evidence supports this biological approach for standard of care in psychiatry. View Full-Text
Keywords: pharmacogenetics; cytochrome p450 enzymes; psychotropic medications; psychiatry; behavior; autism; clinical case pharmacogenetics; cytochrome p450 enzymes; psychotropic medications; psychiatry; behavior; autism; clinical case
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Smith, T.; Sharp, S.; Manzardo, A.M.; Butler, M.G. Pharmacogenetics Informed Decision Making in Adolescent Psychiatric Treatment: A Clinical Case Report. Int. J. Mol. Sci. 2015, 16, 4416-4428.

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