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Int. J. Mol. Sci. 2015, 16(3), 4372-4378; doi:10.3390/ijms16034372

Cell Membrane CD44v6 Levels in Squamous Cell Carcinoma of the Lung: Association with High Cellular Proliferation and High Concentrations of EGFR and CD44v5

1
Molecular Imaging Group, Faculty of Medicine, University of Santiago Compostela, R/de San Francisco, s/n., Santiago de Compostela 15782, Spain
2
Nuclear Medicine Department, University Hospital Santiago Compostela (CHUS), R/Choupana, s/n., Santiago de Compostela 15706, Spain
3
Fundación Tejerina, C/José Abascal, 40, Madrid 28003, Spain
4
General Lab, Hospital Arquitecto Marcide, Ferrol, A Coruña 15405, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 18 November 2014 / Revised: 2 February 2015 / Accepted: 3 February 2015 / Published: 18 February 2015
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [663 KB, uploaded 18 February 2015]

Abstract

Membranous CD44v6 levels in tumors and surrounding samples obtained from 94 patients with squamous cell lung carcinomas were studied and compared to clinical stage, cellular proliferation, membranous CD44v5 levels, epidermal growth factor receptor EGFR and cytoplasmatic concentrations of CYFRA 21.1. CD44v6 positive values were observed in 33/38 non-tumor samples and in 76/94 tumor samples, but there were not statistically significant differences between both subgroups. In CD44v6 positive tumor samples, CD44v6 was not associated with clinical stage, histological grade, ploidy and lymph node involvement, but significant association was found with high cellular proliferation. Likewise, CD44v6 positive tumors had significantly higher levels of EGFR and CD44v5. In patients with squamous cell lung carcinomas and clinical stage I, positive CD44v6 cases were associated with the same parameters. Furthermore, positive CD44v5 squamous tumors were associated significantly with histological grade III and lower levels of CYFRA21.1. Our findings support the value of CD44v6 as a possible indicator of poor outcome in patients with squamous lung carcinomas. View Full-Text
Keywords: lung cancer; squamous lung carcinomas; CD44v6; CD44v5; EGFR; proliferation lung cancer; squamous lung carcinomas; CD44v6; CD44v5; EGFR; proliferation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ruibal, Á.; Aguiar, P.; Del Río, M.C.; Nuñez, M.I.; Pubul, V.; Herranz, M. Cell Membrane CD44v6 Levels in Squamous Cell Carcinoma of the Lung: Association with High Cellular Proliferation and High Concentrations of EGFR and CD44v5. Int. J. Mol. Sci. 2015, 16, 4372-4378.

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