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Int. J. Mol. Sci. 2015, 16(2), 3831-3855; doi:10.3390/ijms16023831

Fatty Acid Signaling: The New Function of Intracellular Lipases

Centre for Experimental Medicine, Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
These authors contributed equally to this work.
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Received: 26 October 2014 / Revised: 19 November 2014 / Accepted: 21 January 2015 / Published: 10 February 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid droplets have been considered to be only passive “energy conserves”. Nevertheless, degradation of TAG gives rise to a pleiotropic spectrum of bioactive intermediates, which may function as potent co-factors of transcription factors or enzymes and contribute to the regulation of numerous cellular processes. From this point of view, the process of lipolysis not only provides energy-rich equivalents but also acquires a new regulatory function. In this review, we will concentrate on the role that fatty acids liberated from intracellular TAG stores play as signaling molecules. The first part provides an overview of the transcription factors, which are regulated by fatty acids derived from intracellular stores. The second part is devoted to the role of fatty acid signaling in different organs/tissues. The specific contribution of free fatty acids released by particular lipases, hormone-sensitive lipase, adipose triacylglycerol lipase and lysosomal lipase will also be discussed. View Full-Text
Keywords: free fatty acids, intracellular signaling, hormone-sensitive lipase, adipose triacylglycerol lipase, lysosomal lipase free fatty acids, intracellular signaling, hormone-sensitive lipase, adipose triacylglycerol lipase, lysosomal lipase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Papackova, Z.; Cahova, M. Fatty Acid Signaling: The New Function of Intracellular Lipases. Int. J. Mol. Sci. 2015, 16, 3831-3855.

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